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    Respiratory depression should be treated as an overdose.
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    These mechanisms may contribute independently to the overall analgesic profile of Isotretinoin.
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    Check with your health care provider before you start, stop, or change the dose of any medicine.Use Isotretinoin as directed by your doctor.

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    alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Isotretinoin ; it may add to their effects.
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    Isotretinoin has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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    Linear pharmacokinetics have been observed following multiple doses of 50 and 100 mg to steady-state.Racemic Isotretinoin is rapidly and almost completely absorbed after oral administration.
    For Isotretinoin, the following should be considered:The suitability of Isotretinoin.
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    Isotretinoin was not mutagenic in the following assays: Ames Salmonella microsomal activation test,
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    The effects of Isotretinoin and its metabolite mono-O-demethyl-Isotretinoin,
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